Journal article
The epileptic network of Lennox-Gastaut syndrome: Cortically driven and reproducible across age
AEL Warren, A Simon Harvey, SJ Vogrin, C Bailey, A Davidson, GD Jackson, DF Abbott, JS Archer
Neurology | LIPPINCOTT WILLIAMS & WILKINS | Published : 2019
Abstract
ObjectiveTo identify brain regions underlying interictal generalized paroxysmal fast activity (GPFA), and their causal interactions, in children and adults with Lennox-Gastaut syndrome (LGS).MethodsConcurrent scalp EEG-fMRI was performed in 2 separately analyzed patient groups with LGS: 10 children (mean age 8.9 years) scanned under isoflurane-remifentanil anesthesia and 15 older patients (mean age 31.7 years) scanned without anesthesia. Whole-brain event-related analysis determined GPFA-related activation in each group. Results were used as priors in a dynamic causal modeling (DCM) analysis comparing evidence for different neuronal hypotheses describing initiation and propagation of GPFA be..
View full abstractGrants
Awarded by LGS Foundation
Funding Acknowledgements
This study was supported by the National Health and Medical Research Council of Australia, project grant 628725 (John S. Archer and David F. Abbott) and practitioner fellowship number 1060312 (Graeme D. Jackson). Aaron E.L. Warren is supported by an Australian Government Research Training Program Scholarship and fellowship funding from the LGS Foundation. David F. Abbott is supported by fellowship funding from the National Imaging Facility. Simon J. Vogrin is supported by the RCH 1,000 Fund within the Developmental Imaging research group at the Murdoch Children's Research Institute and the Children's MRI Centre, Royal Children's Hospital.